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P75 neurotrophin receptor signaling in the nervous system

2019-08-19 22:03

How can the answer be improved?Structural and mechanistic insights into nerve growth p75 neurotrophin receptor and two homologs generates Cterminal factor interactions with the TrkA and p75 receptors. Neuron, 53, fragments with signaling capability. p75 neurotrophin receptor signaling in the nervous system

The lowaffinity nerve growth factor receptor p75 NTR is a major neurotrophin receptor involved in manifold and pleiotropic functions in the developing and adult central nervous system (CNS). Although known for decades, its entire functions are far from being fully elucidated. Depending on the complex interactions with other receptors and on the cellular context, p75 NTR is capable of

Request PDF on ResearchGate p75 Neurotrophin receptor signaling in the nervous system The neurotrophin receptor p75(NTR) has long been known as a receptor for neurotrophins that promote Mar 16, 2016  Introduction. When the immature form of neurotrophin (proneurotrophin) binds p75 together with the Sortilin homodimer, it induces neuronal death and controls responses to neuronal injuries [ 14 16. It is clear that much of the complexity of the neurotrophic signaling has evolved in the vertebrate lineage only, p75 neurotrophin receptor signaling in the nervous system Nov 01, 2002  Von Schack, D. et al. Complete ablation of the neurotrophin receptor p75NTR causes defects both in the nervous and the vascular system. Nat. Neurosci. 4, (2001).

Injury or insult to the adult nervous system often results in reactivation of signaling pathways that are normally only active during development. The p75 neurotrophin receptor (p75 NTR) is one such signaling molecule whose expression increases markedly following neural injury in many of the same cell types that express p75 NTR during development. p75 neurotrophin receptor signaling in the nervous system The neurotrophin receptor p75(NTR) has long been known as a receptor for neurotrophins that promote survival and differentiation. Consistent with the role of neurotrophins, p75(NTR) is expressed during the developmental stages of the nervous system. However, p75(NTR) is reexpressed in various pathological conditions in the adult. Injury or insult to the adult nervous system often results in reactivation of signaling pathways that are normally only active during development. The p75 neurotrophin receptor (p75NTR) is one such signaling molecule whose expression increases markedly following neural injury in many of the same cell types that express p75NTR during development. The neurotrophin receptor p75 NTR has long been known as a receptor for neurotrophins that promote survival and differentiation. Consistent with the role of neurotrophins, p75 NTR is expressed during the developmental stages of the nervous system. However, p75 NTR is reexpressed in various

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